| （Department of Physical Education，Huizhou University，Huizhou 516007，China) Abstract: In order to study the effects of exercise on SREBP-1c signal pathway and fat synthesis of the liver of mice with dyslipidemia induced by RBP4, the author established a dyslipidemia mouse model by means of RBP4 intraperitoneal injection, set up a one-time exercise group (ROE), an 8-week aerobic exercise group (RAE) and a calm control group (RC), and revealed the following findings: comparing the mice in group ROE with the mice in group RC, serum RBP4 level decreased significantly (P<0.01), serum TG and liver TG contents had no significant change (P>0.05); comparing the mice in group RAE with the mice in groups RC and ROE, serum RBP4, serum TG and liver TG contents decreased significantly (P<0.01); comparing the mice in groups ROE and RAE with the mice in group RC, liver SREBP-1c mRNA expression decreased significantly (P<0.01); as for the mice in group ROE, SREBP-1c protein expression, FAS mRNA and FAS protein expression had no significant change (P>0.05); com-paring the mice in group RAE with the mice in group ROE, SREBP-1c, FAS mRNA and protein expression de-creased significantly (P<0.01). The said findings indicate the followings: RBP4 significantly increased mouse liver’s SREBP-1c gene and protein expressions, activated SREBP-1c signal pathway, and promoted liver fat synthe-sis; 8-week aerobic exercise restrained the role of RBP4 in promoting fat synthesis in the liver, improved fat me-tabolism; the mechanism involved with reducing RBP4 level, reducing liver SREBP-1c gene and protein expres-sions, restraining SREBP-1c signal pathway activation, and reducing the liver’s fat synthesis function.
Key words: sports biochemistry；RBP4；SREBP-1c；fat synthesis；mouse |
