(1.Department of Basic Theory,Shandong Institute of Physical Education and Sports,Jinan 250102,China;2.School of Physical Education,South China Normal University,Guangzhou 510006,China) Abstract: IL-7 is an important cytokine for B lymphocytes development and can promote B lymphocytes progeni-tors transition and. Expression of EBF is critical for the lineage specification at the early stage of B cell develop-ment. IL-7 and IL-7R are participants in the formation of the transcription factor network during B lymphopoiesis by maintaining the EBF expression level above a certain threshold. These are necessary for further transition of B cell progenitors. Elevated GC in exercise induces rapidly apoptosis in developing B lymphocytes. It is important and practical for athletes,immune modification to study the lymphocyte development and its regulation. Key words: exercise immunology;bone marrow;B lymphocytes;IL-7;IL-7R;EBF;summary |